An ongoing tribute. An important cause.

The Leland McSpadden
Memorial Research Fund

 

Meaningful Treatment for Lowe syndrome by 2030.

The LSA has an aggressive goal to make accessible a meaningful treatment for Lowe syndrome by 2030. Our international collaboration brings together researchers, clinicians families and those with lived experience. We strive to:
 
Icon for Advance our understanding of the metabolic basis of LS, especially how a phosphatidylinositol enzyme deficiency leads to the various features of LS
Advance our understanding of the metabolic basis of LS, especially how a phosphatidylinositol enzyme deficiency leads to the various features of LS
Icon for Develop a better understanding and treatment of the major complications of LS including but not limited to neurologic and behavioral problems, corneal keloid, degenerative bone and joint disorders, and renal diseases.
Develop a better understanding and treatment of the major complications of LS including but not limited to neurologic and behavioral problems, corneal keloid, degenerative bone and joint disorders, and renal diseases.
Icon for Foster Global Collaboration- LSA-funded research has led to the development of animal models used by researchers for kidney and brain research.
Foster Global Collaboration- LSA-funded research has led to the development of animal models used by researchers for kidney and brain research.
Icon for Support Testing of FDA Approved/Repurposed Drugs: Testing the safety profile, increasing sample sizes, and ultimately moving to clinical trials.
Support Testing of FDA Approved/Repurposed Drugs: Testing the safety profile, increasing sample sizes, and ultimately moving to clinical trials.
Icon for Drive Improvement of a Global Patient Registry: This registry houses the critical data we need to drive research and to understand the nuances between individuals with Lowe syndrome.
Drive Improvement of a Global Patient Registry: This registry houses the critical data we need to drive research and to understand the nuances between individuals with Lowe syndrome.
Icon for Enable LS individuals, Families, Clinical, and Research Experts to Connect: We host international conferences providing a platform for sharing knowledge and fostering collaboration.
Enable LS individuals, Families, Clinical, and Research Experts to Connect: We host international conferences providing a platform for sharing knowledge and fostering collaboration.
About Background




Grant History

2023

SKIP TO YEAR
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Oval
 
2023
Group 5

Dr. Francesco Emma, MD, Head of the Pediatric Nephrology & Department of Pediatric Subspecialties. Bambino Gesù Children’s Hospital, Italy

2023
Group 5

Leopoldo Staino, PhD Telethon Institute of Genetics and Medicine (TIGEM)

2023
Group 5

Dr. Jennifer L. Gallop, Department of Biochemistry University of Cambridge

2021
Group 5

R. Claudio Aguilar, Associate Professor, Assistant Head and Showalter Faculty Scholar, Department of Biological Sciences, Purdue University in West Lafayette, IN

2020
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Herb Lachman, M.D., Professor, Departments of Psychiatry, Medicine, Neuroscience, Genetics, Albert Einstein College of Medicine.

2019
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R. Claudio Aguilar, Associate Professor, Assistant Head and Showalter Faculty Scholar, Department of Biological Sciences, Purdue University in West Lafayette, IN

2018
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Herb Lachman, M.D., Professor, Departments of Psychiatry, Medicine, Neuroscience, Genetics, Albert Einstein College of Medicine.

2018
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R. Claudio Aguilar, Associate Professor, Assistant Head and Showalter Faculty Scholar, Department of Biological Sciences, Purdue University in West Lafayette, IN

2016
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Herb Lachman, M.D., Professor, Departments of Psychiatry, Medicine, Neuroscience, Genetics, Albert Einstein College of Medicine.

2015
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Robert L. Nussbaum, M.D. Chief, Division of Medical Genetics, Department of Medicine and the Institute for Human Genetics, University of California, San Francisco Box 0794, 513 Parnassus Ave, San Francisco, CA.

2014
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Ora A. Weisz, Ph.D., Associate Professor, Departments of Medicine (Renal-Electrolyte Division) and Cell Biology and Physiology, University of Pittsburgh School of Medicine in Pittsburg, PA.

2013
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Antonella De Matteis, MD, Programme Director of Cell Biology of Genetic Diseases, Telethon Institute of Genetics and Medicine (TIGEM) Via Pietro Castellino, 111 Napoli, 80131 Italy

2013
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Yang (“Young”) Sun, M.D., Ph.D. , Assistant Professor of Ophthalmology, Biochemistry and Molecular Biology in Eugene Marilyn Glick Eye Institute of Indiana University School of Medicine, Indianapolis, IN

2013
Group 5

Ora A. Weisz, Ph.D., Associate Professor, Departments of Medicine (Renal-Electrolyte Division) and Cell Biology and Physiology, University of Pittsburgh School of Medicine in Pittsburg, PA

2013
Group 5

Robert L. Nussbaum, M.D., Chief, Division of Medical Genetics, Department of Medicine and the Institute for Human Genetics, University of California, San Francisco Box 0794, 513 Parnassus Ave, San Francisco, CA

2013
Group 5

Antonella De Matteis, MD, Programme Director of Cell Biology of Genetic Diseases, Telethon Institute of Genetics and Medicine (TIGEM) Via Pietro Castellino, 111 Napoli, 80131 Italy

2012
Group 5

Avital Rodal, Ph.D., Associate Professor, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA

2011
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Laura E. Swan, Ph.D., Department of Cell Biology, Yale University School of Medical in New Haven, CT.

2010
Group 5

Avital Rodal, Ph.D., Associate Professor, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA

2009
Group 5

Zelig S. Dolinsky, Ph. D. Biomedical Research Consultant, Manchester, CT

2008
Group 5

Ora A. Weisz, Ph.D., Associate Professor, Departments of Medicine (Renal-Electrolyte Division) and Cell Biology and Physiology, University of Pittsburgh School of Medicine in Pittsburg, PA

2008
Group 5

Pietro De Camilli, M.D., Department. of Cell Biology and HHMI, Yale University School of Medical in New Haven, CT.

2008
Group 5

Zelig S. Dolinsky, Ph. D. Biomedical Research Consultant, Manchester, CT

2007
Group 5

Yuxin Mao, Ph.D., Department. of Cell Biology and HHMI, Yale University School of Medical in New Haven, CT.

2007
Group 5

Ora A. Weisz, Ph.D., Associate Professor, Departments of Medicine (Renal-Electrolyte Division) and Cell Biology and Physiology, University of Pittsburgh School of Medicine in Pittsburg, PA.

2005
Group 5

Maria Antonietta DeMatteis, M.D., Head of the Laboratory of Physiopathology of Secretion within the Department of Cell Biology and Oncology in Consorzio Mario Negri Sud, Chieti, Italy

2003
Group 5

Erik M. Jorgensen, Ph.D., and Kimberly R. Schuske, Ph.D., Department of Biology, University of Utah.

2002
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Erik M. Jorgensen, Ph.D., and Kimberly R. Schuske, Ph.D., Department of Biology, University of Utah.

2002
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Jeremy W. Thorner, Ph.D., Department of Molecular and Cell Biology, University of California/Berkeley.

2000
Group 5

Bonnie Blazer-Yost, Ph.D., Biology Department, Indiana University/Purdue University in Indianapolis, IN.

1999
Group 5

Dewey Royal, Ph.D., Department of Molecular Biology and Biochemistry at Rutgers University.

1999
Group 5

Ti Lin, Ph.D., formerly of the Georgetown University Medical Center, currently at the National Institutes of Health in collaboration with Johns Hopkins Bayview Medical Center.

1999
Group 5

Bonnie Blazer-Yost, Ph.D., Biology Department, Indiana University/Purdue University in Indianapolis, IN.

1996
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Richard A. Lewis, M.D., Baylor College of Medicine.

1993
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Lawrence Charnas, M.D., Ph.D., St. Mary’s Hospital Cancer Research Institute.

1993
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Lorraine C. Racusen, M.D., Johns Hopkins University School of Medicine.

1989
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Richard A. Lewis, M.D., Baylor College of Medicine.

1988
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Richard A. Lewis, M.D., Baylor College of Medicine.